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Aim & Background: Multiple Sclerosis is one of the most common inflammatory central nervous system diseases. In patients, there is a defect in apoptotic pathway making T auto reactive cells non-apoptotic and entering to blood stream. Among the genes related to this disease, there is a gene named CD95L involved in apoptosis pathway. Material & Method: In this survey, we included 30 MS patients and 30 healthy controls which were matched by sex and age. Blood was taken from cases and controls with consent. Next, total RNA was extracted and cDNA was synthesized. Then, by TaqMan Real-time PCR technique, the expression level of CD95L and HGPRT genes was evaluated. The results obtained were analyzed by Linreg and Rest softwares. Result: In this study, CD95L expression in MS patients did not show any significant decrease compared to healthy controls (p Value: 0.197). In addition, in comparison of CD95L expression level between men and women no significant decrease was seen (p Value (M): 0.142, p Value (F): 0.156). Conclusion: In this study, no significant difference of CD95L gene expression between multiple sclerosis patients and healthy controls was seen.

Keywords: Multiple Sclerosis, gene expression, CD95L

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